strontium ranelate (Protelos)

What is strontium ranelate?

Strontium ranelate is a drug treatment for osteoporosis which reduces the risk of broken bones. It comes as granules in a sachet which you take mixed with water on a daily basis. Your doctor will only recommend strontium ranelate if the other drug treatments for osteoporosis are unsuitable for you.

Why do I need a drug treatment for osteoporosis and how does strontium ranelate work?

Drug treatments are prescribed if you have osteoporosis and are at a high risk of broken bones. These treatments help strengthen your bones and reduce your risk of having fractures. They do not help the pain that occurs when bones break. Although it works in a different way from other treatments for osteoporosis, strontium ranelate does not appear to be any better than other treatments in its ability to reduce the risk of broken bones.

Which products contain strontium ranelate?

Protelos

Dose

Licensing Details
* There may be some restrictions on its use in Scotland and Wales.

2g sachet of powder mixed with water daily

F | M | S | H*

Key

F = Post-menopausal women
M = Men
S = shown to reduce the risk of broken bones in the spine
H = shown to reduce the risk of a broken hip
GIOP = shown to reduce the risk of broken bones in people who have osteoporosis caused by glucocorticoid (“steroid”) medication

A licensed drug has been checked for safety and effectiveness and can be prescribed by a doctor for a specific condition.

Sometimes an unlicensed drug will be given at the discretion of your doctor.

How can I get the most out of my drug treatment?

1. Be informed

Find out about your drug treatment so that you can be involved in decisions being made and you will know what to expect. Talk to your doctor and/ or contact the Helpline at the National Osteoporosis Society if you have any questions or concerns.

2. Make sure the drug is properly absorbed

Strontium ranelate is taken once daily preferably at bedtime at least two hours after eating, and at least two hours before any food or drink, other than water. This is because the absorption of the drug may be affected if food or drink other than water is present in the stomach at the same time. If you are taking a calcium supplement, it is particularly important that you do not take it at the same time of day as your strontium ranelate as calcium will prevent its absorption. Some other medications can be taken at the same time as strontium ranelate. Check with your doctor or pharmacist if you are planning to take any other medicines around the same time as your strontium ranelate.

3. Make sure strontium ranelate is the treatment for you

There are some conditions which may mean strontium ranelate is not suitable for you. These are:

  • A history of blood clots. If you are over the age of 80 and at risk of blood clots (see risk factors below) speak to your doctor about a treatment review to make sure the medicine is appropriate for you. Strontium ranelate is now not considered appropriate if you have had a blood clot or are immobile or likely to be, e.g. after an operation. Travelling that involves long periods of immobility (more than five hours) can increase the risk of serious side-effects and, in rare cases, may lead to blood clots. You would usually be advised to take appropriate exercise during the journey and possibly wear elastic hosiery as this can reduce this risk. If you would like specific medical advice about this, speak with your doctor or pharmacist.
  • A history of heart problems. This includes ischemic heart disease, peripheral arterial disease, cerebrovascular disease or uncontrolled blood pressure. Your doctor will monitor you regularly for such problems and the treatment will be stopped should they occur.
  • If you are pregnant or breast feeding (although only licensed for post-menopausal use, occasionally strontium ranelate may be prescribed by specialists for younger women).

4. Continue to take your treatment regularly for the correct length of time

Strontium ranelate is generally prescribed long term so you need to be happy with the treatment. Although it is important that you take the treatment as instructed, missing the odd sachet will probably not have an impact on your bone health in the long run but you should avoid this if you can. If you continually forget or struggle to take your medication it would be sensible to speak to your doctor about other treatment options that you may find easier to take.

Although there is no formal guidance about how long you should take strontium ranelate it is considered good practice for your doctor to review your treatment after a few years.

At this review your doctor will make sure that the drugs are still needed and that they aren’t causing side effects. Your doctor will be able to advise you on what is best for you based on your individual circumstances.

5. Lead a healthy lifestyle to keep your bones strong

Factors that can help to maintain healthy bones are a well-balanced diet with adequate calcium rich foods, safe exposure to sunlight to obtain vitamin D, regular weight bearing exercise, avoiding smoking and keeping alcohol consumption within the recommended limits.

If you have been diagnosed with osteoporosis and are taking a drug treatment, you may need to boost your calcium intake up to around 1000mg a day. Your doctor can prescribe supplements of calcium and/or vitamin D if you need them.

6. Understand the risk of side effects and what can be done to reduce them

As with any drug there are potential side effects with strontium ranelate. It is important to remember that:

    • Most people will not experience side effects or if they do, they are short lived.
    • If you experience problems with the first sachet it is usually worth persevering for a while.
    • Not all the side affects you may read about online or see listed on your patient information are necessarily caused by the drug. This is because symptoms that have been reported by patients taking part in the research trials may be included as possible side effects even if they were seen in as many people who took the placebo (dummy pill) as those taking strontium ranelate . So, common conditions such as bone, muscle and joint pain will often be reported in this way and people may think they are due to their treatment. We can only be sure that such symptoms are likely to be caused by strontium ranelate if they were seen in more patients treated with strontium ranelate than with placebo. The symptoms below are those that can be thought of as “true side effects”

If you are taking medications for other conditions it is important to establish that it is not these that are causing your side effects. Talk to your doctor who may be able to suggest ways of investigating this further.

The full list of possible side effects can be found in the leaflet that accompanies the strontium ranelate sachets. If you experience these or any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist about other treatment options. As more research findings become available more symptoms may be found to be “true side effects” so information could change in the future.